Professor

Veterinary Microbiology Laboratory

Professor

Professor

이종수, Jong-Soo Lee

Major :

예방수의학
Lab. :
수의미생물학실험실
Office Phone :
042-821-6753
Lab Phone :
042-821-7907
E-mail :
jongsool@cnu.ac.kr

3

Education

  • 1992년 ~ 1996년 Bachelor of Veterinary Medicine(DVM), College of Veterinary Medicine, Chungnam National University, Daejeon, Korea

  • 1996년 ~ 1998년Master of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea

  • 1998년 ~ 2001년PhD of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea

  • 2

    Employment

  • 2001. 03 ~ 2005. 09Senior Research Scientist (Military service) Technical Research Center, BioLeaders Corporation, Daejeon, Korea

  • 2005. 10 ~ 2006. 06Senior Research Scientist Technical Research Center, BioLeaders Corporation, Daejeon, Korea

  • 2006. 08 ~ 2007. 12Research fellow Microbiology and Molecular Genetics, Tumor Virology Division, Harvard Medical School (Advisor : Dr. Jae U. Jung)

  • 2008. 01 ~ 2010. 02Research fellow Molecular Microbiology and Immunology, Harlyne J. Norris Cancer Research Center, University of Southern California (Advisor : Dr. Jae U. Jung)

  • 2010. 03 ~ 2014. 02Assistant Professor Veterinary Microbiology, College of Veterinary Medicine, Chungnam National University

  • 2014. 03 ~ 2018. 02Associate Professor Veterinary Microbiology, College of Veterinary Medicine, Chungnam National University

  • 2018. 03 ~ PresentProfessor Veterinary Microbiology, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea

  • 1

    Selected Publications

  • Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation. Cell Reports. 2023. 113358.

  • The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation. Frontiers in Immunology. 2023. 14: 1242183.

  • MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria. EMBO Journal. 2023. e113481. (*Co-corresponding Authors)

  • Foot-and-mouth disease virus non-structural protein 2B downregulates the RLR signaling pathway via degradation of RIG-I and MDA5. Frotiers in Immunology. 2022. 13: 1020262.

  • Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing. Experimental & Molecular Medicine. 2021. 53(11):1647.

  • Negative regulation of the NEMO signaling by the ubiquitin E3 ligase MARCH2. EMBO Journal. 2020. 39(21):e105139.

  • Foot-and-Mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation. PLOS Pathogens. 2020. 16(11):e1009057

  • SHP Controls the Virus-Mediated Antiviral Immune Response by Targeting CBP in the Nucleus. Cell Reports. 2019. 14: 2015-2118.

  • Fas-associated factor 1 Mediates NADPH Oxidase-Induced Reactive Oxygen Species Production and Proinflammatory Responses in Macrophages against Listeria Infection. PLOS Pathogens. 2019. 14;15(8):e1008004

  • Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis. Experimental & Molecular Medicine. 2019. 51: 128. (*Co-corresponding Authors)

  • FAS-associated factor-1 positively regulates Type I interferon response to RNA virus infection by targeting NLRX1. PLOS Pathogens. 2017. 13(5): e1006398.

  • Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity by promoting MAVS stabilization. Nature Immunology. 2016. 17: 1252-1262. (*Co-corresponding Authors)

  • HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I. EMBO Journal. 2016. 35: 429-442. (*Co-corresponding Authors)(Highlighted in Nature Immunology. 2016)

  • The Mitochondrial Ubiquitin Ligase MARCH5 Resolves MAVS Aggregates during Antiviral Signaling. Nature Communications. 2015. 6:7910. (*Co-corresponding Authors)

  • Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host & Microbe. 2012. 11:264-276. (*Co-First Authors)

  • FLIP-mediated autophagy in cell death control. Nature Cell Biology. 2009 11:1355-62. (주저자)

  • Immunogenicity of surface displayed viral antigens on Salmonella carrier vaccine. Nature Biotechnology. 2000. 18:645-648. (주저자)

  • Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation Cell Reports

  • The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation Frontiers in Immunology